A bispecific antibody approach
Step 1 – Guided inhibition
Bispecific antibodies bind Tumor Associated Antigen (TAA) with high affinity and block CD47 upon co-engagement at the cell surface. CD47 expressed by TAA-negative healthy cells is not bound or inhibited.
Step 2 – Enhanced Antibody Dependent Cellular Phagocytosis (ADCP)
ADCP is induced by antibody Fc (human IgG1) binding to Fc receptors on phagocytes (macrophages or dendritic cells). Tumor cell phagocytosis is increased by the blockade of the CD47-SIRPa interaction, the «don’t eat me signal».
Step 3 – Activation of the adaptive immune response
Dendritic Cells and Macrophages process and cross-present tumor antigens to T lymphocytes leading to the induction anti-tumor immunity and potentially durable responses.
Interested by this approach for your own projects? Partner with us
