We first identify antibodies using our common heavy chain antibody libraries. Then, we simply co-express one heavy chain and the two light chains. The bispecific κλ bodies can be directly tested using the cell culture supernatant or easily purified using standard affinity chromatography.
Native, non-engineered, human bispecific antibodies maintain human antibody sequence and structure.
A κλ body consists of:
- 2 identical heavy chains
- 2 different light chains: one kappa (κ) and one lambda (λ)
